![Importin 8 (IPO8)](/upload/item/img/Importin-8-(IPO8)-90206.jpg)
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Importin 8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase.
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Human RANBP8 and Xenopus RanBP7 share 61% amino acid identity. They both belong to a Ran-binding protein superfamily whose members share with importin-beta an N-terminal sequence motif that appears to account for RanGTP binding. IPO8 was required for AGO2 binding to a large set of target mRNAs, and knockdown of IPO8 led to a moderate increase of target mRNAs. Knockdown of IPO8 had no effect on AGO stability, miRNA biogenesis, or miRNA loading onto AGO proteins.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Importin 8 (IPO8) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Importin 8 (IPO8) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Importin 8 (IPO8) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Importin 8 (IPO8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Importin 8 (IPO8) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA206Mu01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA206Mu01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Importin 8 (IPO8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Importin 8 (IPO8) | ELISA Kit Customized Service Offer |
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