≡

Glycoprotein IX, Platelet (GP9)

[Edit]

CD42-A; CD42a; GPIX; Glycoprotein 9

Glycoprotein IX, Platelet (GP9)
CCC A197
HGNC 4444
MGI 1860137
PubMed 23336709
RGD 1561601
UniProt P14770
Wiki GpIX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene. Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA) and a beta chain (GP1BB), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5).

 

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA197Hu01 Recombinant Glycoprotein IX, Platelet (GP9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA197Hu01 Polyclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
MAA197Hu24 Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
MAA197Hu25 Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
MAA197Hu27 Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
MAA197Hu22 Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
MAA197Hu21 Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glycoprotein IX, Platelet (GP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycoprotein IX, Platelet (GP9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycoprotein IX, Platelet (GP9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycoprotein IX, Platelet (GP9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycoprotein IX, Platelet (GP9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycoprotein IX, Platelet (GP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycoprotein IX, Platelet (GP9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA197Ra01 Recombinant Glycoprotein IX, Platelet (GP9) Positive Control; Immunogen; SDS-PAGE; WB.
RPA197Ra02 Recombinant Glycoprotein IX, Platelet (GP9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA197Ra01 Polyclonal Antibody to Glycoprotein IX, Platelet (GP9) WB; IHC; ICC; IP.
PAA197Ra02 Polyclonal Antibody to Glycoprotein IX, Platelet (GP9) WB,IHC
Assay Kits n/a CLIA Kit for Glycoprotein IX, Platelet (GP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycoprotein IX, Platelet (GP9) ELISA Kit Customized Service Offer
  1. "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3."FEBS Lett. 274:189-192(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the gene encoding human platelet glycoprotein IX."J. Biol. Chem. 268:3438-3443(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures."Proc. Natl. Acad. Sci. U.S.A. 86:6773-6777(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Corrected DNA sequence of the platelet glycoprotein IX gene."Thromb. Haemost. 77:1034-1035(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of human platelet glycoprotein IX."Biochem. Biophys. Res. Commun. 156:931-939(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome."Blood 81:2339-2347(1993) [PubMed] [Europe PMC] [Abstract]
  9. "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome."Br. J. Haematol. 97:312-320(1997) [PubMed] [Europe PMC] [Abstract]
  10. "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV."Br. J. Haematol. 103:1004-1013(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome."Br. J. Haematol. 107:539-545(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome."Br. J. Haematol. 112:105-108(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient."Zhonghua Xue Ye Xue Za Zhi 22:464-466(2001) [PubMed] [Europe PMC] [Abstract]
  14. "A Leu7-to-Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex."Br. J. Haematol. 118:260-266(2002) [PubMed] [Europe PMC] [Abstract]