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Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D)

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CD264; TNFRSF10-D; DCR2; TRAILR4; TRUNDD; Decoy receptor 2; TNF-Related Apoptosis-Inducing Ligand Receptor 4; TRAIL Receptor With a Truncated Death Domain

Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D)
CCC A138
HGNC 11907
PubMed 22028813
UniProt Q9UBN6
Wiki TNFRSF10D

is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.

Independently, Marsters et al. (1997) and Pan et al. (1998) isolated cDNAs encoding TRAILR4, which they designated 'decoy receptor-2' (DCR2) and 'TRAIL receptor with a truncated death domain' (TRUNDD), respectively.

By analysis of radiation hybrid panels, Degli-Esposti et al. (1997) and Marsters et al. (1997) mapped the TRAILR4 gene to 8p21, in a cluster with the genes encoding TRAILR1, TRAILR2, and TRAILR3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10D (TNFRSF10D) ELISA Kit Customized Service Offer
  1. "A novel receptor for Apo2L/TRAIL contains a truncated death domain."Curr. Biol. 7:1003-1006(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain."Immunity 7:813-820(1997) [PubMed] [Europe PMC] [Abstract]
  3. "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling."FEBS Lett. 424:41-45(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]