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Neurotrophin 4 (NT4)

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NT5; NTF4; NT-4/5; Neurotrophic Factor 4; Neurotrophin-5

Neurotrophin 4 (NT4)
CCC A107
HGNC 8024
MGI 97381
PubMed 10631974
RGD 3212
UniProt P34130
Wiki Neurotrophin4

Neurotrophin-4 (NT-4) like BDNF, is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. It is also known as NT4, NT5, NTF4, and NT-4/5. Differentiation, survival, and function of neurons in vertebrates are controlled by multiple, target-derived neurotrophic factors. The best characterized mammalian neurotrophic factors are 4 structurally related 13- to 14-kD basic proteins known as neurotrophinsBerkemeier et al. (1992) identified a cluster of genes on human chromosome 19 that includes neurotrophin-5 (NT5) and 3 pseudogenes, designated NTF6A, NTF6B, and NTF6G. The NTF5 and NTF6 gene loci were mapped to chromosome 19 by Southern analysis of somatic cell hybrid panels. In the mouse, the Ntf5 gene was assigned to chromosome 7.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA107Hu01 Recombinant Neurotrophin 4 (NT4) Positive Control; Immunogen; SDS-PAGE; WB.
APA107Hu01 Active Neurotrophin 4 (NT4) Cell culture; Activity Assays.
Antibodies PAA107Hu01 Polyclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
MAA107Hu22 Monoclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
Assay Kits SEA107Hu ELISA Kit for Neurotrophin 4 (NT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA107Mu01 Recombinant Neurotrophin 4 (NT4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA107Mu02 Recombinant Neurotrophin 4 (NT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA107Mu01 Polyclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
PAA107Mu02 Polyclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
Assay Kits SEA107Mu ELISA Kit for Neurotrophin 4 (NT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA107Ra01 Recombinant Neurotrophin 4 (NT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA107Ra01 Polyclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
MAA107Ra21 Monoclonal Antibody to Neurotrophin 4 (NT4) WB; IHC; ICC; IP.
Assay Kits SEA107Ra ELISA Kit for Neurotrophin 4 (NT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Xenopus (Clawed frog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurotrophin 4 (NT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurotrophin 4 (NT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurotrophin 4 (NT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurotrophin 4 (NT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophin 4 (NT4) ELISA Kit Customized Service Offer
  1. "Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB."Neuron 7:857-866(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity."Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site."Protein Sci. 8:2589-2597(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma."Am. J. Hum. Genet. 85:447-456(2009) [PubMed] [Europe PMC] [Abstract]
  6. "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma."Am. J. Hum. Genet. 86:498-499(2010) [PubMed] [Europe PMC] [Abstract]