Matrix Metalloproteinase 13 (MMP13)

MMP-13 has been proposed to participate in aggrecan degradation associated with osteoarthritis and cleavage of type II collagen in osteoarthritic cartilage explants and in tumor progression and metastasis . In addition, it can cleave type I, III, IV, IX, X and XIV collagens and fibronectin. MMP-13 is likely to play a crucial role in the modulation of extracellular matrix degradation and cell-matrix interactions .MMP-13 is expressed by several metastatic tumors including breast carcinomas, chondrosarcomas, head and neck carcinomas, and in degenerative bone diseases including rheumatoid arthritis. Wild type and mutant p53, a tumor suppressor gene, differentially regulate MMP-13 gene expression . Members of the activator protein-1 and core-binding factor families increase MMP-13 promoter activity in normal, differentiating osteoblasts .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Hu01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Hu02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
APA099Hu02 Active Matrix Metalloproteinase 13 (MMP13) Cell culture; Activity Assays.
APA099Hu01 Active Matrix Metalloproteinase 13 (MMP13) Cell culture; Activity Assays.
Antibodies PAA099Hu01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Hu22 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB
PAA099Hu02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB
LAA099Hu71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB
MAA099Hu21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) IHC; ICC/IF
MAA099Hu23 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) IHC
MAA099Hu24 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) IHC
MAA099Hu25 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) IHC
MAA099Hu27 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Hu29 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Hu ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Hu CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
HEA099Hu High Sensitive ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Mu01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Mu02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Mu01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Mu02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB
LAA099Mu71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
Assay Kits SEA099Mu ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Mu CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
HEA099Mu High Sensitive ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ra01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Ra02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
EPA099Ra61 Eukaryotic Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
APA099Ra61 Active Matrix Metalloproteinase 13 (MMP13) Cell culture; Activity Assays.
Antibodies PAA099Ra01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB,IHC
PAA099Ra02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Ra71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
Assay Kits SEA099Ra ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Ra CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Rb01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Rb02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Rb03 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Rb53 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Rb51 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) ICC/IF
PAA099Rb52 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Rb71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
LAA099Rb81 FITC-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IF.
PAA099Rb01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Rb02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Rb ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Rb CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ca01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Ca01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 13 (MMP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 13 (MMP13) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Po01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Po01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Po21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Po ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Po CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Bo01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Bo01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Bo21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Bo ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Bo CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Cp01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Cp01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Cp21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 13 (MMP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 13 (MMP13) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Eq01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Eq01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB
MAA099Eq21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Eq ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Eq CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ga01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Ga01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Ga21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Ga ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Ga CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
  1. "Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas."J. Biol. Chem. 269:16766-16773(1994) [PubMed] [Europe PMC] [Abstract]
  2. "A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas."Immunobiology 198:375-384(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical characterization of human collagenase-3."J. Biol. Chem. 271:1544-1550(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme."J. Biol. Chem. 271:17124-17131(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Degradation of cartilage aggrecan by collagenase-3 (MMP-13)."FEBS Lett. 380:17-20(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes."J. Biol. Chem. 271:23577-23581(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."Dev. Dyn. 208:387-397(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction."J. Biol. Chem. 272:7608-7616(1997) [PubMed] [Europe PMC] [Abstract]
  11. "A secreted tyrosine kinase acts in the extracellular environment."Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain."J. Mol. Biol. 264:556-566(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."Nat. Struct. Biol. 6:217-221(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1."J. Mol. Biol. 301:513-524(2000) [PubMed] [Europe PMC] [Abstract]
  15. "High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor."J. Mol. Biol. 302:671-689(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14." Bioorg. Med. Chem. Lett. 15:1807-1810(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for the highly selective inhibition of MMP-13."Chem. Biol. 12:181-189(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."J. Biol. Chem. 282:27781-27791(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."J. Mol. Biol. 366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13." J. Med. Chem. 52:3523-3538(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis." Bioorg. Med. Chem. Lett. 20:576-580(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease." J. Med. Chem. 53:6653-6680(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins."J. Biol. Chem. 287:26647-26656(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Hydantoin based inhibitors of MMP13--discovery of AZD6605."Bioorg. Med. Chem. Lett. 23:4705-4712(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain."FASEB J. 27:4395-4405(2013) [PubMed] [Europe PMC] [Abstract]
  26. "MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."J. Clin. Invest. 115:2832-2842(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."Am. J. Hum. Genet. 85:168-178(2009) [PubMed] [Europe PMC] [Abstract]