≡

Insulin Like Growth Factor 2 (IGF2)

[Edit]

INSIGF; IGF-II; Somatomedin A; Preptin; Insulin-like growth factor II Ala-25 Del

Insulin Like Growth Factor 2 (IGF2)
CCC A051
HGNC 5466
MGI 96434
PubMed 20499340
RGD 2870
UniProt P01344
Wiki IGF2

IGF2 is a regulatory peptide (IGF-II) critical for normal fetal growth. It has been shown to be implicated in tumor progression in a variety of human neoplasms, eg, Wilms' tumors and rhabdomyosarcomas.

IGF2 transcription is controlled by four distinct promoters, P1 to P4, of which promoters P2, P3, and P4 are epigenetically regulated by genomic imprinting. The IGF-II protein can bind to different receptors: the IGF-I receptor (IGF-IR) has classically been regarded as the major mediator of its proliferative effect; the insulin receptor (IR), especially its isoform A (IR-A), which resembles the IGF-IR in its effect; and the IGF-II receptor (IGF-IIR), which internalizes IGF-II into the cell, thereby regulating its extracellular concentration, and eventually leading to its lysosomal degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Hu01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA051Hu01 Active Insulin Like Growth Factor 2 (IGF2) Cell culture; Activity Assays.
Antibodies PAA051Hu01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
MAA051Hu22 Monoclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
LAA051Hu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC.
LAA051Hu81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IF.
Assay Kits SEA051Hu ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA051Hu CLIA Kit for Insulin Like Growth Factor 2 (IGF2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Mu01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA051Mu02 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA051Mu01 Active Insulin Like Growth Factor 2 (IGF2) Cell culture; Activity Assays.
Antibodies PAA051Mu01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
LAA051Mu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC.
LAA051Mu81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IF.
PAA051Mu02 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits SEA051Mu ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA051Mu CLIA Kit for Insulin Like Growth Factor 2 (IGF2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Ra01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA051Ra01 Active Insulin Like Growth Factor 2 (IGF2) Cell culture; Activity Assays.
Antibodies PAA051Ra01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
LAA051Ra71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC.
LAA051Ra81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IF.
MAA051Ra21 Monoclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits SEA051Ra ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Gu01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Gu01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 (IGF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 (IGF2) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Rb01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA051Rb61 Eukaryotic Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Rb51 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
MAA051Rb21 Monoclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits SEA051Rb ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Po01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Po01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
MAA051Po21 Monoclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits SEA051Po ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Bo01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Bo01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
MAA051Bo21 Monoclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits SEA051Bo ELISA Kit for Insulin Like Growth Factor 2 (IGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Cp01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Cp01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 (IGF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 (IGF2) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor 2 (IGF2) Recombinant Protein Customized Service Offer
Antibodies PAA051Ov01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 (IGF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 (IGF2) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Eq01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Eq01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 (IGF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 (IGF2) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA051Ga01 Recombinant Insulin Like Growth Factor 2 (IGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA051Ga01 Polyclonal Antibody to Insulin Like Growth Factor 2 (IGF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 (IGF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 (IGF2) ELISA Kit Customized Service Offer
  1. "Insulin-like growth factor II precursor gene organization in relation to insulin gene family."Nature 310:777-781(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence of a cDNA clone encoding human preproinsulin-like growth factor II."Nature 310:775-777(1984) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta."Proc. Natl. Acad. Sci. U.S.A. 85:1947-1951(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of the human genes for insulin-like growth factors I and II."FEBS Lett. 195:179-184(1986) [PubMed] [Europe PMC] [Abstract]
  5. "Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions."Proc. Natl. Acad. Sci. U.S.A. 84:6330-6334(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression."Methods Enzymol. 146:239-248(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant."FEBS Lett. 179:243-246(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II."Jpn. J. Cancer Res. 86:202-207(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human."Hum. Mol. Genet. 15:1259-1269(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2)."Mol. Biol. Rep. 38:1515-1521(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein."Biochim. Biophys. Acta 950:282-295(1988) [PubMed] [Europe PMC] [Abstract]
  16. "A new 5'-non-coding region for human placental insulin-like growth factor II mRNA expression."FEBS Lett. 222:181-185(1987) [PubMed] [Europe PMC] [Abstract]
  17. "Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene."DNA 6:283-295(1987) [PubMed] [Europe PMC] [Abstract]
  18. "Primary structure of human insulin-like growth factor II."FEBS Lett. 89:283-286(1978) [PubMed] [Europe PMC] [Abstract]
  19. "Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing."J. Biol. Chem. 264:9314-9321(1989) [PubMed] [Europe PMC] [Abstract]
  20. "Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta."J. Chromatogr. B 666:203-214(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males."Hum. Mol. Genet. 10:1491-1501(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Detection of bound and free IGF-1 and IGF-2 in human plasma via biomolecular interaction analysis mass spectrometry."FEBS Lett. 536:130-134(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative mass spectrometric immunoassay of insulin like growth factor 1."J. Proteome Res. 3:851-855(2004) [PubMed] [Europe PMC] [Abstract]
  24. "The identification of O-glycosylated precursors of insulin-like growth factor II."J. Biol. Chem. 267:8153-8160(1992) [PubMed] [Europe PMC] [Abstract]
  25. "Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo."Am. J. Physiol. 292:E117-E122(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes."J. Med. Genet. 46:192-197(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  29. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  30. "Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors."Fed. Proc. 42:2592-2597(1983) [PubMed] [Europe PMC] [Abstract]
  31. "Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins."EMBO J. 13:5590-5597(1994) [PubMed] [Europe PMC] [Abstract]
  32. "Structure and functional analysis of the IGF-II/IGF2R interaction."EMBO J. 27:265-276(2008) [PubMed] [Europe PMC] [Abstract]