Bone Morphogenetic Protein Receptor 2 (BMPR2)
[Edit]BMPRII; BMPR-II; BRK3; T-ALK; BMPR3; PPH1; Primary Pulmonary Hypertension 1; BMP type II receptor
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Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates. The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.Unlike the TGFβ type II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. In TGF beta signaling all of the receptors exist in homodimers before ligand binding.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA016Hu01 | Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA016Hu01 | Active Bone Morphogenetic Protein Receptor 2 (BMPR2) | Cell culture; Activity Assays. | |
Antibodies | PAA016Hu01 | Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) | WB; ICC; IHC-P; IHC-F; ELISA. |
Assay Kits | SEA016Hu | ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Bone Morphogenetic Protein Receptor 2 (BMPR2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEA016Ra | ELISA Kit for Bone Morphogenetic Protein Receptor 2 (BMPR2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "Crystal structure of the BMPR2 kinase domain."Submitted (FEB-2009) to the PDB data bank
- "Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."Am. J. Hum. Genet. 67:737-744(2000) [PubMed] [Europe PMC] [Abstract]
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- "Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations."PLoS ONE 9:E106703-E106703(2014) [PubMed] [Europe PMC] [Abstract]