Activated Leukocyte Cell Adhesion Molecule (ALCAM)
[Edit]CD166; MEMD; Activated Leucocyte Cell Adhesion Molecule
ALCAM/CD166 is a member of the immunoglobulin gene superfamily belonging to a subgroup with five extracellular immunoglobulin-like domains(VVC2C2C2), which includes MCAM/CD146/MUC18 and B-CAM/Lutheran. These molecules are involved in the development and maintenance of tissue architecture, neurogenesis, hematopoiesis, immune responses and tumor progression. ALCAM/CD166 mediates cell-cell clustering through homophilic (ALCAM-ALCAM) and heterophilic (ALCAM-CD6) interactions. Its pattern of expression in human tissues and cells is broad and includes epithelia, neurons, lymphoid and myeloid cells, hematopoietic and mesenchymal stem cells. The relevance of the engagement of the heterophilic pair CD166-CD6 for optimal activation of T cells has been recently demonstrated.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA002Hu01 | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA002Hu01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. |
MAA002Hu22 | Monoclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. | |
LAA002Hu71 | Biotin-Linked Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC. | |
LAA002Hu81 | FITC-Linked Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IF. | |
MAA002Hu21 | Monoclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. | |
Assay Kits | SEA002Hu | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA002Hu | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA002Mu01 | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA002Mu01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB,IHC |
Assay Kits | n/a | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA002Ra01 | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA002Ra01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. |
LAA002Ra71 | Biotin-Linked Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC. | |
LAA002Ra81 | FITC-Linked Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IF. | |
Assay Kits | n/a | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA002Rb01 | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA002Rb51 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. |
PAA002Rb01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. | |
Assay Kits | n/a | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Recombinant Protein Customized Service Offer |
Antibodies | PAA002Po01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA002Bo01 | Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA002Bo01 | Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Activated Leukocyte Cell Adhesion Molecule (ALCAM) | ELISA Kit Customized Service Offer |
- "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand."J. Exp. Med. 181:2213-2220(1995) [PubMed] [Europe PMC] [Abstract]
- "Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function."J. Biol. Chem. 279:55315-55323(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)."Am. J. Pathol. 152:805-813(1998) [PubMed] [Europe PMC] [Abstract]
- "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM."Biochemistry 35:12287-12291(1996) [PubMed] [Europe PMC] [Abstract]
- "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM."Protein Sci. 4:1644-1647(1995) [PubMed] [Europe PMC] [Abstract]