Gremlin 1 (GREM1)
[Edit]PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1
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Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem 1 inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development .
Grem 1 regulation of BMP-4 in mice embryos is essential in kidney and lung branching morphogenesis. Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma survival and proliferation in some cancers. Grem 1 expression is found in many cancers and is thought to play important roles in uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma carcinomas.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC128Hu01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC128Hu02 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC128Hu02 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. | |
| APC128Hu01 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. | |
| Antibodies | PAC128Hu01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| MAC128Hu22 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB,IHC | |
| LAC128Hu71 | Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC. | |
| LAC128Hu81 | FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IF. | |
| PAC128Hu02 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. | |
| MAC128Hu21 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. | |
| MAC128Hu23 | Monoclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC128Hu | ELISA Kit for Gremlin 1 (GREM1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC128Mu01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC128Mu02 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC128Mu01 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. | |
| Antibodies | PAC128Mu01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB,IHC |
| LAC128Mu71 | Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC. | |
| LAC128Mu81 | FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IF. | |
| PAC128Mu02 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC128Mu | ELISA Kit for Gremlin 1 (GREM1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC128Ra01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC128Ra01 | Active Gremlin 1 (GREM1) | Cell culture; Activity Assays. | |
| Antibodies | PAC128Ra01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| Assay Kits | SEC128Ra | ELISA Kit for Gremlin 1 (GREM1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC128Ga01 | Recombinant Gremlin 1 (GREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC128Ga01 | Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC; IP. |
| LAC128Ga71 | Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Gremlin 1 (GREM1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Gremlin 1 (GREM1) | ELISA Kit Customized Service Offer |
- "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
- "IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1."J. Biol. Chem. 275:9901-9904(2000) [PubMed] [Europe PMC] [Abstract]
- "DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain."Cytogenet. Cell Genet. 89:79-84(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1."Nat. Genet. 44:699-703(2012) [PubMed] [Europe PMC] [Abstract]