Gremlin 1 (GREM1)

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PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1

Gremlin 1 (GREM1)

Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem 1 inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development .

Grem 1 regulation of BMP-4 in mice embryos is essential in kidney and lung branching morphogenesis. Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma survival and proliferation in some cancers. Grem 1 expression is found in many cancers and is thought to play important roles in uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC128Hu01 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC128Hu02 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
APC128Hu02 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
APC128Hu01 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
Antibodies PAC128Hu01 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
MAC128Hu22 Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
LAC128Hu71 Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC.
LAC128Hu81 FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
PAC128Hu02 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
Assay Kits SEC128Hu ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC128Mu01 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC128Mu02 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
APC128Mu01 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
Antibodies PAC128Mu01 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
LAC128Mu71 Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC.
LAC128Mu81 FITC-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
PAC128Mu02 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
Assay Kits SEC128Mu ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC128Ra01 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
APC128Ra01 Active Gremlin 1 (GREM1) Cell culture; Activity Assays.
Antibodies PAC128Ra01 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gremlin 1 (GREM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gremlin 1 (GREM1) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC128Ga01 Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC128Ga01 Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
LAC128Ga71 Biotin-Linked Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Gremlin 1 (GREM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gremlin 1 (GREM1) ELISA Kit Customized Service Offer
  1. "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
  2. "IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1."J. Biol. Chem. 275:9901-9904(2000) [PubMed] [Europe PMC] [Abstract]
  3. "DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain."Cytogenet. Cell Genet. 89:79-84(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1."Nat. Genet. 44:699-703(2012) [PubMed] [Europe PMC] [Abstract]