Leukemia Inhibitory Factor (LIF)

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CDF; D-FACTOR; HILDA; MLPLI; Cholinergic Differentiation Factor; Differentiation-Stimulating Factor; Melanoma-Derived LPL Inhibitor; Emfilermin

Leukemia Inhibitory Factor (LIF)

Leukemia inhibitory factor, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukaemic cells. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.

LIF is normally expressed in the trophectoderm of the developing embryo, with its receptor LIFR expressed throughout the inner cell mass. As embryonic stem cells are derived from the inner cell mass at the blastocyst stage, removing them from the inner cell mass also removes their source of LIF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Hu01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
APA085Hu01 Active Leukemia Inhibitory Factor (LIF) Cell culture; Activity Assays.
Antibodies PAA085Hu01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
MAA085Hu22 Monoclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits SEA085Hu ELISA Kit for Leukemia Inhibitory Factor (LIF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Mu01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
APA085Mu01 Active Leukemia Inhibitory Factor (LIF) Cell culture; Activity Assays.
Antibodies PAA085Mu01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukemia Inhibitory Factor (LIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukemia Inhibitory Factor (LIF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Ra01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA085Ra01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
MAA085Ra21 Monoclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits SEA085Ra ELISA Kit for Leukemia Inhibitory Factor (LIF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Ca01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA085Ca01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukemia Inhibitory Factor (LIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukemia Inhibitory Factor (LIF) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Po01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
CPA085Po21 OVA Conjugated Leukemia Inhibitory Factor (LIF) Immunogen; SDS-PAGE; WB.
Antibodies PAA085Po01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
MAA085Po21 Monoclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
PAA085Po08 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits SEA085Po ELISA Kit for Leukemia Inhibitory Factor (LIF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Bo01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA085Bo01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits SEA085Bo ELISA Kit for Leukemia Inhibitory Factor (LIF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA085Cp01 Recombinant Leukemia Inhibitory Factor (LIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA085Cp01 Polyclonal Antibody to Leukemia Inhibitory Factor (LIF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukemia Inhibitory Factor (LIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukemia Inhibitory Factor (LIF) ELISA Kit Customized Service Offer
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  2. "Genomic cloning and heterologous expression of human differentiation-stimulating factor."DNA 8:351-359(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions."J. Biol. Chem. 265:8833-8841(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor."Proc. Natl. Acad. Sci. U.S.A. 85:2623-2627(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia."Biochem. Biophys. Res. Commun. 160:1085-1092(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor."Arch. Biochem. Biophys. 302:484-489(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
  12. "An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor."Proc. Natl. Acad. Sci. U.S.A. 104:12737-12742(2007) [PubMed] [Europe PMC] [Abstract]