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Hepatic HuR modulates lipid homeostasis in response to high-fat diet
On June 16, 2020, professorZhongzhou Yang from model animal research centerof Nanjing university co-authored with Wengong Wang from Peking university health science centerpublished apaper titledHepatic HuR modulates lipid homeostasis in response to high-fat dietonNature communications.The ELISA kit (APOE, SEA704Mu; APOB, SEC003Mu) of Cloud-Clone brand was chosed to determine the concentation of APOE and APOBin this article, we are so proud for supporting the reaserchers.Lipid transport and ATP synthesis are critical for the progression of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are largely unknown. Here, we report that the RNA-binding protein HuR (ELAVL......
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Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress
On June24, 2020, professorMutsuhiro Takekawa frominstitute of medical science of university of Tokyopublished apaper titledStress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustainedactivation of SAPKs by oxidative stressonScience Advances.The polyclonalantibody(GADD45b,PAL535Hu01) ofCloud-Clone brand was chosed to conduct immunoprecipitationin this article, we are so proud for supporting the reaserchers.Cells respond to oxidative stress by inducing intracellular signaling, including stress-activated p38 and JNK MAPK (SAPK) pathways, but the underlying mechanisms remain unclear. Here, we report that the MAP three kinase 1 (MTK1) SAPK kinase kinase (SAPKKK......
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A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial
On June24, 2020, professorChim C LangfromDivision of Molecular & Clinical Medicineof University of Dundeepublished apaper titledA randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people withtype two diabetes: the DAPA-LVH trialonEuropean Heart Journal.The ELISA kit (PIIINP, CEA573Hu) ofCloud-Clone brand was chosed to determine the concentation ofPIIINPin this article, we are so proud for supporting the reaserchers.Patients with type 2 diabetes (T2D) mellitus have double the risk of cardiovascular death (CVD) compared with people without T2D. Heart failure is an important manifestation of diabetic heart disease. Men with diabetes are twice as likely to hav......
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RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells
On April 29, 2020, professorAkiyoshi UemurafromKobe University Graduate School of Medicinepublished apaper titledRhoJ integrates attractive and repulsive cues in directionalmigration of endothelial cellsonEMBO JOURNAL.The ELISA kit (Sema3E, SEL920Mu) ofCloud-Clone brand was chosed to determine the concentation of Sema3Ein this article, we are so proud for supporting the reaserchers.During angiogenesis, VEGF acts as an attractive cue for endothelial cells (ECs), while Sema3E mediates repulsive cues. Here, we show that the small GTPase RhoJ integrates these opposing signals in directional EC migration. In the GTP-bound state, RhoJ interacts with the cytoplasmic domain of PlexinD1. Upon S......
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A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
On April 24, 2020, professorXian-Zheng ZhangfromKey Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistryof Wuhan University published apaper titledA vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy onNature communications.The ELISA kit (MIP1a, SEA092Mu; HA, CEA927Ge) of Cloud-Clone brand was chosed to determine the concentation of MIP1a and HAin this article, we are so proud for supporting the reaserchers.The unsatisfactory response rate of immune checkpoint blockade (ICB) immunotherapy severely limits its clinical application as a tumor therapy. Here, we generate a vaccine-based nanosystem by integrating siRNA fo......
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Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling
On May 15, 2020, professorWangjun LiaofromDepartment of Oncologyof Nanfang Hospitalof Southern Medical Universityco-authored with Malcolm Xing from Faculty of Agricultureof University of Manitobapublished apaper titledGold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signalingon ACS NANO.The ELISA kit (VEGFA, SEA143Hu; SEMA3A, SEL917Hu) of Cloud-Clone brand was chosed to determine the concentation of VEGFA and SEMA3Ain this article, we are so proud for supporting the reaserchers.Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery properties and inherent antineoplastic activity. Here, we focused on......
