Polyclonal Antibody to Angiotensin II (AngII)

Ang-II; Angiotensin-2


The antibody is a rabbit polyclonal antibody raised against AngII. It has been selected for its ability to recognize AngII in immunohistochemical staining and western blotting.


Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Magazine Citations
Nature Medicine Angiotensin-Converting Enzyme 2 Overexpression Remarkably Ameliorated Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition MolMed: 10_11_liu
The European Journal of Clinical Investigation Mesangial medium with IgA1 from IgA nephropathy inhibits nephrin expression in mouse podocytes Wiley: source
Immunopharmacology and Inflammation Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid ScienceDirect: S0188440910001049
Nephrology Effect of aggregated immunoglobulin A1 from immunoglobulin A nephropathy patients on nephrin expression in podocytes Wiley: source
PLoS One Angiotensin II and Angiotensin-(1-7) in Paraventricular Nucleus Modulate Cardiac Sympathetic Afferent Reflex in Renovascular Hypertensive Rats PubMed: PMC3527547
BioMed Research International Heterogeneous Downregulation of Angiotensin II AT1-A and AT1-B Receptors in Arterioles in STZ-Induced Diabetic Rat Kidneys Hindawi: 947506
34 Biglcan is beneficial in angiotensin II induced heart failure by preventing cardiac inflammation and remodeling improving LV function and mortality by preventing transdifferentiation of myofibroblasts Oxfordjournals: Source
Pflügers Archiv-European Journal of Physiology SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats Pubmed: 23114721
Eur J Pharmacol. Angiotensin II and vasopressin are involved in the defense system against anaphylactic hypotension in anesthetized rats Pubmed:24650734
J Mol Cell Cardiol. Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction Pubmed:25871829
Mol Med Rep. High glucose induces activation of the local renin?angiotensin system in glomerular endothelial cells Pubmed:24337709
Mol Med Rep. Angiotensin II promotes the progression of human gastric cancer Pubmed:24424956
PLOS ONE Intermedin in the Paraventricular Nucleus Attenuates Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats Pubmed:24709972
Journal of Vascular Surgery Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice Pubmed:25037606
Biochim Biophys Acta. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis Pubmed:25092171
Acta Physiologica Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats Pubmed:25307720
Neuroscience Letters Administration of exogenous 1,25(OH)2D3 normalizes overactivation of the central renin-angiotensin system in 1α(OH)ase knockout mice Pubmed:25576706
34 A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling PubMed: 26069213
Life Sci Cardioprotective effects of baicalein on heart failure via modulation of Ca2 PubMed: 26706290
Physiological Research Renal Sympathetic Denervation Improves Cardiac Dysfunction PubMed: 25804096
Nutrition Effects of Rubus occidentalis extract on blood pressure in subjects with prehypertension: randomized, double-blinded, placebo controlled clinical trial PubMed: 26740254
J Am Soc Hypertens Angiotensin-(1–7) enhances the effects of angiotensin II on the cardiac sympathetic afferent reflex and sympathetic activity in rostral ventrolateral medulla in renovascular hypertensive rats PubMed: 26428223
PLoS One. Up ReCavia (Guinea pig )lation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol–Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats Pubmed:26963622
Nutrition Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial Pubmed:26740254
Journal of Atherosclerosis and Thrombosis Involvement of Angiotensin II Type 1 and 2 Receptors in Gelatinase ReCavia (Guinea pig )lation in Human Carotid Atheroma in vitro Pubmed:26947595
Mol Neurobiol A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats Pubmed:26867655
Life Sci Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro Pubmed:26706290
PLoS One. Paradoxical Sleep Deprivation Causes Cardiac Dysfunction and the Impairment Is Attenuated by Resistance Training. pubmed:27880816
Oxidative Medicine and Cellular Longevity Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic db/db Mice pubmed:27698952
Journal of the Renin-Angiotensin-Aldosterone System Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin converting enzyme-2/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury 1470320316661871.abstract
Microvascular Research Pleiotropic effects of survivin in vascular endothelial cells. pubmed:27373518
PLOS ONE Reduced Expression of the Extracellular Calcium-Sensing Receptor (CaSR) Is Associated withActivation of the Renin-Angiotensin System (RAS) to Promote Vascular Remodeling in the Pathogenesis of Essential Hypertension. pubmed:27391973
journal of pharmacological sciences β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibitionof renal fibroblast activation and fibrosis. pubmed:28433566
Experimental Animals Ginsenoside Rb1 improves cardiac function and remodeling in heart failure. pubmed:28367863
Oncotarget Effects of renal denervation on monocrotaline induced pulmonary remodeling pubmed:28187460
The American Journal of Pathology The Renin-Angiotensin System Regulates Neurodegeneration in a Mouse Model of Optic Neuritis pubmed:28919108
PLoS One Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy pubmed:29240788
Frontiers in Physiology Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression pubmed:29066981
Neurotherapeutics Brain Renin–Angiotensin System Blockade Attenuates Methamphetamine-Induced Hyperlocomotion and Neurotoxicity Pubmed:29464572
International Journal of Cardiology ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in … Pubmed:29506687
Neuroscience Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats Pubmed:29684507
American Journal of Physiology-Renal Physiology Role of (Pro) Renin Receptor in Albumin Overload-Induced Nephropathy in Rats Pubmed:29846109
Journal of the American Society of Hypertension Mesenchymal stem cell–derived microvesicles alleviate pulmonary arterial hypertension by regulating renin-angiotensin system Pubmed:29752040
Evidence-based Complementary and Alternative Medicine  Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects Pubmed:29977313
Brazilian Journal of Medical and Biological Research Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection Pubmed:29590257
American Journal of Physiology-Heart and Circulatory Physiology Sex Differences in the Central and Peripheral Manifestations of Ischemia-induced Heart Failure in Rats Pubmed: 30289294
Toxicology Mechanisms and Methods Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats Pubmed: 30426860
Journal of Clinical and Aesthetic Dermatology Detection of Angiotensin II and AT1 Receptor Concentrations in Keloid and Hypertrophic Scar.
International Journal of Ophthalmology Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes Pubmed: 30588418
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH ACE Gene Plays a Key Role in Reducing Blood Pressure in The Hyperintensive Elderly After Resistance Training Pubmed: 30908459
The American Journal of the Medical Sciences T lymphocyte-based renin angiotensin system in obesity
Journal of Alzheimers Disease Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer's Disease Pubmed: 31594235
Andrologia Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status Pubmed: 31989676
Molecular Medicine Reports BPA disrupts 17‑estradiol‑mediated hepatic protection against ischemia/reperfusion injury in rat liver by upregulating the Ang II/AT1R signaling pathway Pubmed: 32319667
MOLECULAR MEDICINE REPORTS The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta … Pubmed: 32319652
Cell Mol Neurobiol Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors Pubmed: 33201417
biochemistry biophysical reports Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats Pubmed: 33024842
bioscience reports Angiotensin II enhances the proliferation of Natural Killer/T-cell lymphoma cells via activating PI3K/Akt signaling pathway Pubmed: 32969473
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY A (pro) renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting intrarenal renin-angiotensin system Pubmed: 32865014
JOURNAL OF PROTEOME RESEARCH Proteomics and informatics for understanding phases and identifying biomarkers in COVID-19 disease Pubmed: 32657586
Scientific Reports Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats Pubmed: 32616735
BIOMEDICINE & PHARMACOTHERAPY Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats Pubmed: 32570115
CLINICAL AND EXPERIMENTAL HYPERTENSION Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats Pubmed: 32349626
Evidence-Based Complementary and Alternative Medicine Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats Pubmed: 33133215
Oxidative Medicine and Cellular Longevity Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression Pubmed: 32765804
Nutrition Gut Dysbiosis Contribute to High Fructose Induced Salt Sensitive Hypertension In Sprague-Dawley Rats
Dikkat Eksikliği Hiperaktivite Bozukluğu Tanısı Olan Anjiyotensin I, II, III, Alamandin peptid, Anjiyotensin Dönüştürücü Enzim (ACE), NADPH Oksidaz Enzim Serum …
Physiol Behav Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1-7 and vasopressin 33340514
ACTA PHARMACOLOGICA SINICA The vascular endothelial growth factor trap aflibercept induces vascular dysfunction and hypertension via attenuation of eNOS/NO signaling in mice 33303990
Int J Hypertens The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models 33884205
Physiol Rep (Pro) renin receptor antagonist PRO20 attenuates nephrectomy©\induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/¦Â©\catenin signaling 34057312
Redox Biology Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney 33360353
Basic and Clinical Neuroscience Paeonol Protects Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease 33995926
researchsquare Ang-(1-7) Protects Skeletal Muscle Function in Aged Mice
Molecular Medicine Reports Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats 34278476
BMC Musculoskeletal Disorders Ang-(1–7) protects skeletal muscle function in aged mice 34548056
J Am Heart Assoc Maternal Angiotensin II–Induced Hypertension Sensitizes Postweaning High‐Fat Diet–Elicited Hypertensive Response Through Increased Brain Reactivity in Rat … 34482712
Biomed Pharmacother Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti … 34736077
J Am Heart Assoc Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension‐Induced Hypertensive Response Sensitization Elicited by Postweaning … Pubmed:35014859
J Gerontol A Biol Sci Med Sci Dysregulation of ACE-1 in normal aging and the early stages of Alzheimer's disease Pubmed:35396835
Biomedicine & Pharmacotherapy Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway Pubmed:35658238
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
CPA005Mi21 OVA Conjugated Angiotensin II (AngII) Immunogen; SDS-PAGE; WB.
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PAA005Mi01 Polyclonal Antibody to Angiotensin II (AngII) WB; IHC; ICC; IP.
MAA005Mi21 Monoclonal Antibody to Angiotensin II (AngII) WB; IHC; ICC; IP.
MAA005Mi01 Monoclonal Antibody to Angiotensin II (AngII) WB; IHC; ICC; IP.
MAA005Mi27 Monoclonal Antibody to Angiotensin II (AngII) WB; IHC; ICC; IP;ELISA