Anti-Voltage Gated Calcium Channel Complex Antibody (Anti-VGCC)

Autoantibodies to a restricted set of self-proteins are a feature of some central nervous system (CNS) disorders. Antibodies to the glutamate receptors, phospholipids, cardiolipin, and glutamic acid decarboxylase (GAD) are associated with different forms of epilepsy, whereas antibodies to voltage-gated potassium channels (VGKCs) and voltage-gated calcium channels

(VGCCs) have been associated with certain forms of limbic encephalitis and cerebellar ataxia. The diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) is usually made on clinical grounds and confirmed by electrodiagnostic studies.  A serum test for voltage-gated calcium channel antibodies (VGCC) is commercially available.  Treatment involves removing the cancer associated with the disease.  If cancer is not found, immunosuppressive medications and acetylcholinesterase inhibitors are used with moderate success.