Pyridoxal Phosphate (PLP)

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P5P; Pyridoxal-5'-Phosphate;, PAL-P; Vitamin B6 Phosphate

Pyridoxal Phosphate (PLP)
Pyridoxal-phosphate isthe active form of vitamin B6, which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. This co-factor acts as an electron sink to stabilize carbanionic intermediates in both substitution and elimination reactions involving aminated compounds. PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. The aldehyde group of PLP forms a Schiff-base linkage with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Pyridoxal Phosphate (PLP) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyridoxal Phosphate (PLP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyridoxal Phosphate (PLP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyridoxal Phosphate (PLP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyridoxal Phosphate (PLP) ELISA Kit Customized Service Offer