Agmatine (Agm)

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4-Aminobutyl Guanidine

Agmatine (Agm)
Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is discussed as a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to α2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits or inactivates nitric oxide synthase (NOS), and it induces the release of some peptide hormones. agmatine administered orally abolished the depressive-like behavior induced by the administration of the pro-inflammatory cytokine, tumor necrosis factor (TNF-α) in mice. Agmatine exerts antidepressant like effects via NPYergic system possibly mediated by the NPY Y1 receptor subtypes in rats.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Agmatine (Agm) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Agmatine (Agm) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Agmatine (Agm) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Agmatine (Agm) CLIA Kit Customized Service Offer
n/a ELISA Kit for Agmatine (Agm) ELISA Kit Customized Service Offer