Acacetin (AC)

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Linarigenin; Acacetine; Buddleoflavonol; Linarisenin; 4'-Methoxyapigenin

Acacetin (AC)
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, has anti-peroxidative and anti-inflammatory effects. The effect of acacetin on antimetastasis in human prostate cancer DU-145 cells was investigated. First, the result demonstrated acacetin could exhibit an inhibitory effect on the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay, wound-healing assay, and Boyden chamber assay. Data also showed acacetin could inhibit the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) involved in the downregulation of the expressions of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and urokinase-type plasminogen activator (u-PA) at both the protein and mRNA levels. Next, acacetin significantly decreased the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Acacetin (AC) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acacetin (AC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acacetin (AC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acacetin (AC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acacetin (AC) ELISA Kit Customized Service Offer