Evodiamine is a chemical extracted from the Tetradium family of plants, which has been shown to reduce fat uptake in mouse studies. It is suspected that its mechanism of action is similar to that of capsaicin. As such, it has been included in some dietary supplements. Neither its fat-burning effects in humans nor any potential side effects have been empirically established. Evodiamine acts primarily as a thermogenic and stimulant. Evodiamine may also act in a manner comparable to tianeptine by increasing the number of serotonin transporters available in the brain, enhacing the reuptake of serotonin. Evodiamine showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodiamine has no perceptible taste, including a peppery hot taste.
-V959.gif)