Procarbazine (PC)

Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents.Its mechanism of action is not fully understood. Metabolism yields azo-procarbazine and hydrogen peroxide[citation needed] which results in the breaking of DNA strands. When used to treat Hodgkin's Lymphoma (HL), it is often delivered as part of the BEACOPP regimen that includes Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine (tradename Oncovin), Prednisone, and Procarbazine. The first combination chemotherapy developed for Hodgkin's Lymphoma, MOPP also included Procarbazine (ABVD has supplanted MOPP as standard first line treatment for HL, with BEACOPP as an alternative for advanced/unfavorable HL).