Robinin (Rob)
Robinin is a chemical compound. It can be isolated from Vinca erecta or from the common locust Robinia pseudoacacia. The hPBMCs were isolated from healthy human volunteers and the cells were cultured in collagen coated plates at 37°C with 5% CO2 and RPMI as culture medium and were grouped as follows: Group I - control, group II - OxLDL treated and group III - OxLDL+robinin (6μg/ml). Robinin inhibited the ox-LDL induced TLR2 and TLR4 expression at mRNA level and inhibited the translocation of NF-κB p65 by modulating the TLR-NF-κB signaling pathway thereby inhibiting cytokine production and down regulated inflammatory enzymes like cyclooxygenase (COX), lipoxygenase (LOX), nitric oxide synthase (NOS) and prostaglandin E2 (PGE2), thus having protective effect against the ox-LDL induced inflammation stress in hPBMCs by inhibiting TLR4-NF-κB signaling pathway.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Robinin (Rob) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Robinin (Rob) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Robinin (Rob) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Robinin (Rob) CLIA Kit Customized Service Offer
n/a ELISA Kit for Robinin (Rob) ELISA Kit Customized Service Offer