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Notch2 N-Terminal Like Protein (NOTCH2NL)

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N2N

Notch2 N-Terminal Like Protein (NOTCH2NL)
CCC S272
HGNC 31862
PubMed 24140581
UniProt Q7Z3S9
N2N is a 36-kDa protein distributed throughout the cell and secreted. Its amino-terminal sequence consists of several EGF repeats identical to those of the extracellular region of Notch2, and its carboxyl terminus contains a unique 24-residue domain required for interaction with neutrophil elastase. Neutrophil elastase cleaves N2N within EGF repeats in vitro and in living cells, but the C-terminal domain retards proteolysis.
In vitro, N2N represses transcriptional activities of Notch proteins. Disease-causing mutations of neutrophil elastase disrupt the interaction with N2N, impair proteolysis of N2N and Notch2, and interfere with Notch2 signaling, suggesting defective proteolysis of an inhibitory form of Notch as an explanation for the alternate switching of cell fates characteristic of hereditary neutropenia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS272Hu01 Recombinant Notch2 N-Terminal Like Protein (NOTCH2NL) Positive Control; Immunogen; SDS-PAGE; WB.
RPS272Hu02 Recombinant Notch2 N-Terminal Like Protein (NOTCH2NL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAS272Hu01 Polyclonal Antibody to Notch2 N-Terminal Like Protein (NOTCH2NL) WB; IHC
MAS272Hu21 Monoclonal Antibody to Notch2 N-Terminal Like Protein (NOTCH2NL) WB; IHC; ICC; IP.
Assay Kits SES272Hu ELISA Kit for Notch2 N-Terminal Like Protein (NOTCH2NL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia."Mol. Cell. Biol. 24:58-70(2004) [PubMed] [Europe PMC] [Abstract]