Zymogen Granule Protein 16 Homolog B (ZG16B)

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JCLN2; Jacalin-Like Lectin Domain Containing 2

Zymogen Granule Protein 16 Homolog B (ZG16B)
ZG16b/PAUF has recently been found to play a role in gene regulation and cancer metastasis. However, the detailed functions of ZG16p and ZG16b remain to be clarified. ZG16p has a Jacalin-related β-prism fold, the first to be reported among mammalian lectins. The putative sugar-binding site of ZG16p is occupied by a glycerol molecule, mimicking the mannose bound to Jacalin-related mannose-binding-type plant lectins such as Banlec. ZG16b also has a β-prism fold, but some amino acid residues of the putative sugar-binding site differ from those of the mannose-type binding site suggesting altered preference. A positively charged patch, which may bind sulfated groups of the glycosaminoglycans, is located around the putative sugar-binding site of ZG16p and ZG16b. The sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS158Hu01 Recombinant Zymogen Granule Protein 16 Homolog B (ZG16B) Positive Control; Immunogen; SDS-PAGE; WB.
RPS158Hu02 Recombinant Zymogen Granule Protein 16 Homolog B (ZG16B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAS158Hu01 Polyclonal Antibody to Zymogen Granule Protein 16 Homolog B (ZG16B) WB; ICC/IF;FCM
MAS158Hu21 Monoclonal Antibody to Zymogen Granule Protein 16 Homolog B (ZG16B) WB; IHC; ICC; IP.
Assay Kits SES158Hu ELISA Kit for Zymogen Granule Protein 16 Homolog B (ZG16B) Enzyme-linked immunosorbent assay for Antigen Detection.
SCS158Hu CLIA Kit for Zymogen Granule Protein 16 Homolog B (ZG16B) Chemiluminescent immunoassay for Antigen Detection.
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  6. "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold."Biochem. Biophys. Res. Commun. 404:201-205(2011) [PubMed] [Europe PMC] [Abstract]