Leucine Rich Repeat Containing Protein 15 (LRRC15)
[Edit]LIB; Leucine-rich repeat protein induced by beta-amyloid homolog
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LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. Together, these observations define the consequence of (KTS) insertion within WT1-derived zinc fingers, and identify a novel EWS-WT1 transcriptional target implicated in tumor invasiveness.
LRRC15, however, does not impede p53 function per se but impedes adenoviral infection. Specifically, LRRC15 causes redistribution of the coxsackievirus-adenovirus receptor away from the cell surface.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Leucine Rich Repeat Containing Protein 15 (LRRC15) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEQ887Hu | ELISA Kit for Leucine Rich Repeat Containing Protein 15 (LRRC15) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | EPQ887Mu61 | Eukaryotic Leucine Rich Repeat Containing Protein 15 (LRRC15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEQ887Mu | ELISA Kit for Leucine Rich Repeat Containing Protein 15 (LRRC15) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | EPQ887Ra61 | Eukaryotic Leucine Rich Repeat Containing Protein 15 (LRRC15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leucine Rich Repeat Containing Protein 15 (LRRC15) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Leucine Rich Repeat Containing Protein 15 (LRRC15) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Leucine Rich Repeat Containing Protein 15 (LRRC15) | ELISA Kit Customized Service Offer |
- "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid."Biochem. Biophys. Res. Commun. 290:756-762(2002) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein."Genes Dev. 17:2094-2107(2003) [PubMed] [Europe PMC] [Abstract]