Melanoma Antigen Family A3 (MAGEA3)
[Edit]MAGE3; HYPD; HIP8; CT1.3; Melanoma-Associated Antigen 3; Antigen MZ2-D; MAGE-3 Antigen; Cancer/Testis Antigen Family 1, Member 3
![Melanoma Antigen Family A3 (MAGEA3)](/upload/item/img/Melanoma-Antigen-Family-A--3-(MAGEA3)--84282.jpg)
MAGEA3 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. MAGE3 cDNA was cloned from a melanoma cell cDNA library. The gene encodes a 314-amino acid polypeptide. RT-PCR revealed that MAGE2 is expressed in a variety of cancer cell lines, but among normal tissues only in testis and placenta.MAGEA3 gene comprises 3 exons, with the last exon containing the entire coding sequence.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ282Hu01 | Recombinant Melanoma Antigen Family A3 (MAGEA3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Melanoma Antigen Family A3 (MAGEA3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Melanoma Antigen Family A3 (MAGEA3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEQ282Hu | ELISA Kit for Melanoma Antigen Family A3 (MAGEA3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes."J. Exp. Med. 179:921-930(1994) [PubMed] [Europe PMC] [Abstract]
- "Cloning and analysis of MAGE-1-related genes."Biochem. Biophys. Res. Commun. 202:549-555(1994) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Comparative genome sequence analysis of the Bpa/Str region in mouse and man." Genome Res. 10:758-775(2000) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
- "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
- "Human class I histocompatibility antigen (HLA-A complex with a nonameric peptide from melanoma-associated antigen 3 (residues 271-279)."Submitted (FEB-2009) to the PDB data bank