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MHC Class I Polypeptide Related Sequence A (MICA)

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PERB11.1

MHC Class I Polypeptide Related Sequence A (MICA)
CCC P871
HGNC 7090
PubMed 23727634
UniProt Q29983
Wiki MICA
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.The MICA gene encodes a 383-amino acid polypeptide with a predicted mass of 43 kD. It is further distinguished by its unusual exon-intron organization and preferential expression in fibroblasts and epithelial cells. However, the presence of distinctive residues in the MICA amino acid sequence translated from cDNA suggested that the putative MICA chain folds similarly to typical class I chains and may have the capacity to bind peptide or other short ligands.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APP871Hu01 Active MHC Class I Polypeptide Related Sequence A (MICA) Cell culture; Activity Assays.
RPP871Hu01 Recombinant MHC Class I Polypeptide Related Sequence A (MICA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP871Hu21 Monoclonal Antibody to MHC Class I Polypeptide Related Sequence A (MICA) WB; IHC; ICC; IP.
Assay Kits SEP871Hu ELISA Kit for MHC Class I Polypeptide Related Sequence A (MICA) Enzyme-linked immunosorbent assay for Antigen Detection.
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  36. "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
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