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MHC Class I Polypeptide Related Sequence B (MICB)

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PERB11.2

MHC Class I Polypeptide Related Sequence B (MICB)
CCC P870
HGNC 7091
PubMed 16636811
UniProt Q29980
Wiki MICB
MICB encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. MICB is a stress-induced ligand of the NK cell-activating receptor NKG2D and is critical for the NK cell killing of virus-infected cells and tumor cells.
With intestinal epithelial cell lines, expression and recognition of MICA and MICB could be stress induced; thus, these molecules may broadly regulate protective responses by the V-delta-1 gamma/delta T cells in the epithelium of the intestinal tract.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APP870Hu01 Active MHC Class I Polypeptide Related Sequence B (MICB) Cell culture; Activity Assays.
RPP870Hu01 Recombinant MHC Class I Polypeptide Related Sequence B (MICB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to MHC Class I Polypeptide Related Sequence B (MICB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MHC Class I Polypeptide Related Sequence B (MICB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MHC Class I Polypeptide Related Sequence B (MICB) CLIA Kit Customized Service Offer
n/a ELISA Kit for MHC Class I Polypeptide Related Sequence B (MICB) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of a human MHC class I MICB cDNA."Immunogenetics 43:230-233(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the human MHC class I MICB gene."Immunogenetics 45:161-162(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence."Hum. Immunol. 68:705-707(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Allelic and interlocus comparison of the PERB11 multigene family in the MHC."Immunogenetics 45:209-216(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Allelic repertoire of the human MICB gene."Immunogenetics 46:434-436(1997) [PubMed] [Europe PMC] [Abstract]
  9. "A novel major histocompatibility complex class I-related chain allele."Tissue Antigens 64:74-77(2004) [PubMed] [Europe PMC] [Abstract].
  10. "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles."Tissue Antigens 51:649-652(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Allelic variants of the human MHC class I chain-related B gene (MICB)."Immunogenetics 46:499-508(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Three novel MICB alleles."Tissue Antigens 55:166-170(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients."Tissue Antigens 64:276-280(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells."Science 279:1737-1740(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB."Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)."Biochim. Biophys. Acta 1526:10-12(2001) [PubMed] [Europe PMC] [Abstract]
  17. "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family."Immunogenetics 53:279-287(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells."Immunogenetics 54:671-674(2002) [PubMed] [Europe PMC] [Abstract]
  20. "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid."Int. J. Cancer 104:354-361(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection."J. Immunol. 170:1249-1256(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients."Hum. Immunol. 67:188-195(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function."Proc. Natl. Acad. Sci. U.S.A. 103:11258-11263(2006) [PubMed] [Europe PMC] [Abstract]
  26. "In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer."PLoS ONE 2:E518-E518(2007) [PubMed] [Europe PMC] [Abstract]
  27. "MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility."Rheumatology 46:426-430(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk."Schizophr. Res. 94:342-353(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Host immune system gene targeting by a viral miRNA."Science 317:376-381(2007) [PubMed] [Europe PMC] [Abstract]
  30. "Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine."Biochem. Biophys. Res. Commun. 370:578-583(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D."J. Immunol. 169:1395-1400(2002) [PubMed] [Europe PMC] [Abstract]