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Linker For Activation Of T-Cells Family, Member 2 (LAT2)

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WBSCR15, WBSCR5; WSCR5, HSPC046, LAB, NTAL; Williams-Beuren Syndrome Chromosome Region 5; Linker For Activation Of B Cells; Non-T Cell Activation Linker

Linker For Activation Of T-Cells Family, Member 2 (LAT2)
CCC P555
HGNC 12749
MGI 1926479
PubMed 8812460
RGD 631397
UniProt Q9GZY6
Wiki LAT2
LAT2 is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.Sequence analysis predicted that human WBSCR5 is a 243-amino acid nuclear protein, only 48% identical to the mouse sequence, that contains no known motifs. Northern blot analysis detected strong expression of a 1.9-kb transcript in peripheral blood leukocytes, placenta, and lung, with lower expression in spleen, heart, brain, liver, and pancreas.NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Phosphorylation of NTAL was strongest in the presence of LCK, ZAP70, SYK, or LYN.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP555Hu01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP555Hu01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP555Mu01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP555Mu01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP555Ra01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP555Ra01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB
Assay Kits n/a CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) ELISA Kit Customized Service Offer
  1. "Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome."Cytogenet. Cell Genet. 90:285-290(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23."Mamm. Genome 11:890-898(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling."J. Exp. Med. 196:1617-1626(2002) [PubMed] [Europe PMC] [Abstract]
  4. "LAB: a new membrane-associated adaptor molecule in B cell activation."Nat. Immunol. 4:117-123(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation."Blood 104:207-214(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB."J. Biol. Chem. 279:11229-11235(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Transmembrane adaptor molecules: a new category of lymphoid-cell markers."Blood 107:213-221(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]