Liriodendrin (Lir)
Liriodendrin is an antiarrhythmic lignan isolated from Pittosporum. A new triterpene, 21-O-senecioyl-R(1)-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl(2)-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl(2)-induced arrhythmias.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Liriodendrin (Lir) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Liriodendrin (Lir) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Liriodendrin (Lir) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Liriodendrin (Lir) CLIA Kit Customized Service Offer
n/a ELISA Kit for Liriodendrin (Lir) ELISA Kit Customized Service Offer