Dihydroresveratrol (DHR)

Dihydro-resveratrol is a dihydrostilbenoid found in wine. It is also a metabolite of trans-resveratrol formed in the intestine by the hydrogenation of the double bond by microflora.Dihydroresveratrol is a metabolite of trans-resveratrol formed in the intestine by the hydrogenation of the double bond by microflora.Dihydroresveratrol was extracted from acidified plasma with a C18 cartridge, eluted with methanol, and concentrated prior to HPLC analysis with diode-array detection (HPLC-DAD) at 276 nm. The average recovery was 96.7% and the limit of detection was 275 nM. The oral administration of dihydroresveratrol to rats and its subsequent detection, along with dihydroresveratrol glucuronide and sulfate, provides evidence of its absorption and metabolism..