Baccatin III (BC3)
Baccatin III, a precursor for the semisynthesis of taxol, is widely considered to be an inactive derivative of taxol. Here we show that baccatin III efficiently enhances MHC-restricted antigen presentation in dendritic cells. Baccatin III increased both class I- and class II-restricted presentation of exogenous OVA in bone marrow-derived dendritic cells (BM-DCs). Baccatin III also increased class I-restricted presentation of virus-encoded endogenous OVA in BM-DCs. Baccatin III did not affect the phagocytic activity of BM-DCs. The antigen presentation-enhancing activity of baccatin III was examined further with nanoparticles containing OVA and baccatin III. Inclusion of baccatin III to nanoparticles containing OVA greatly enhanced their capacity to induce class I-restricted OVA peptide presentation in DCs both in vitro and in vivo.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Baccatin III (BC3) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baccatin III (BC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baccatin III (BC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baccatin III (BC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baccatin III (BC3) ELISA Kit Customized Service Offer