Astragalin (Ast)

Astragalincan be isolated from Phytolacca americana or in the methanolic extract of fronds of the fern Phegopteris connectilis. It is also found in wine. The exposure to paraoxon (3.63 μmol/L) resulted in an inhibition of the EDRR, markedly reduced the level of nitric oxide (NO), the activity of paraoxonase1 (PON1) and superoxide dismutase (SOD), and significantly increased the level of malondialdehyde (MDA) in isolated rat thoracic aorta. However, the presence of astragalin (10 μmol/L) markedly attenuated the vascular endothelium dysfunction induced by paraoxon via increasing level of NO, activity of PON1 and SOD, as well as reducing level of MDA. Astragalin could protect the vascular endothelium against the paraoxon-induced dysfunction in isolated rat thoracic aorta, and the beneficial effects of astragalin might be concerned with the antioxidation of astragalin due to inhibiting the decreased activity of PON1.