Adenanthin (Ade)
Adenanthin, a diterpenoid isolated from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. We show that adenanthin directly targets the conserved resolving cysteines of Prx I and Prx II and inhibits their peroxidase activities. Consequently, cellular H(2)O(2) is elevated, leading to the activation of extracellular signal-regulated kinases and increased transcription of CCAAT/enhancer-binding protein β, which contributes to adenanthin-induced differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid. Thus, adenanthin can serve as what is to our knowledge the first lead natural compound for the development of Prx I- and Prx II-targeted therapeutic agents, which may represent a promising approach to inducing differentiation of APL cells.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Adenanthin (Ade) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenanthin (Ade) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenanthin (Ade) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenanthin (Ade) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenanthin (Ade) ELISA Kit Customized Service Offer