Bromethalin (BM)

Bromethalin is a rodenticide which poisons the central nervous system by uncoupling mitochondrial oxidative phosphorylation, which causes a decrease in adenosine triphosphate (ATP) synthesis. Decreased ATP ultimately results in increased intracranial pressure, which damages neuronal axons. This damage to the central nervous system can cause paralysis, convulsions, and death. There are no tests that will diagnose bromethalin poisoning in pets, but signs to watch for include severe muscle tremors, hyperexcitability, fits, extreme sensitivity to being touched (hyperesthesia) and seizures that appear to be caused by light or noise. Signs can be delayed for several days. There is no antidote for bromethalin:care is symptomatic and supportive. Animals who have eaten it accidentally should seek immediate veterinary attention and be decontaminated.