Helenalin (HLN)
Helenalin is a sesquiterpene lactone found in Arnica montana and Arnica chamissonis foliosa. Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract. Helenalin has a variety of observed effects in vitro including anti-inflammatory and antitumor activities. Helenalin has been shown to selectively inhibit the transcription factor NF-κB, which plays a key role in regulating immune response, through a unique mechanism. In vitro, it is also a potent, selective inhibitor of human telomerase—which may partially account for its antitumor effects—has anti-trypanosomal activity, and is toxic to Plasmodium falciparum.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Helenalin (HLN) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Helenalin (HLN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Helenalin (HLN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Helenalin (HLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Helenalin (HLN) ELISA Kit Customized Service Offer