Methylenedioxyethylamphetamine (MDEA)

MDEA is a psychedelic and entactogenic drug of the phenethylamine and amphetamine chemical classes. Like MDA, MDEA acts as a serotonin, norepinephrine, and dopamine releasing agent. The subjective effects of MDEA are very similar to those of MDMA. However, the euphoric and "loved up" feelings associated with MDMA are not as pronounced in comparison. It is said to be stoning in high doses. A method is described for the simultaneous determination of the ratio of l- and d-enantiomers of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) in urine. The assay uses liquid-liquid extraction followed by derivatization with trifluoroacetyl-l-prolyl chloride (l-TPC) and analysis by gas chromatography-mass spectrometry.