Yessotoxin (YTX)
Yessotoxin (YTX) is a marine polyether toxin previously described as a phosphodiesterase (PDE) activator in fresh human lymphocytes. This toxin induces a decrease of adenosine 3',5'-cyclic monophosphate (cAMP) levels in fresh human lymphocytes in a medium with calcium (Ca(2+) ), whereas the contrary effect has been observed in a Ca(2+) -free medium. In the present article, the effect of YTX in K-562 lymphocytes cell line has been analysed. Surprisingly, results obtained in K-562 cell line are completely opposite than in fresh human lymphocytes, since in K-562 cells YTX induces an increase of cAMP levels. YTX cytotoxicity was also studied in both K-562 cell line and fresh human lymphocytes. Results demonstrate that YTX does not modify fresh human lymphocytes viability, whereas in K-562 cells, YTX has a highly cytotoxic effect.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Yessotoxin (YTX) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Yessotoxin (YTX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Yessotoxin (YTX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Yessotoxin (YTX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Yessotoxin (YTX) ELISA Kit Customized Service Offer