Piribedil (PBD)

Piribedil is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties. The drug has been shown to enhance working memory capacities in normal aging adults. In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes. As with other dopamine agonists (like pramipexole and ropinirole), compulsive behavior like pathological gambling, overeating, excessive shopping, increased libido, sexual and/or other intense urges, may develop. Another rare side effect of piribedil is excessive daytime sleepiness and unintended sleep episodes. Dopamine antagonists reduce the effect of piribedil