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HAUS Augmin Like Complex Subunit 7 (HAUS7)

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UCHL5IP; UIP1; UCHL5 Interacting Protein; UCH37 Interacting Protein 1; 26S Proteasome-Associated UCH Interacting Protein 1; X-linked protein STS1769

HAUS Augmin Like Complex Subunit 7 (HAUS7)
CCC M623
HGNC 32979
MGI 1920988
RGD 1562991
UniProt Q99871
HAUS7 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly.
UIP1 bound to full-length mouse Uch37 and to its C-terminal extension, but not to its N-terminal domain. In vitro binding assays confirmed direct interaction between UIP1 and Uch37. Furthermore, UIP1 was found to inhibit interaction between the S14 proteasome subunit (PSMD8) and Uch37 in a concentration-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM623Hu01 Recombinant HAUS Augmin Like Complex Subunit 7 (HAUS7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAM623Hu71 Biotin-Linked Polyclonal Antibody to HAUS Augmin Like Complex Subunit 7 (HAUS7) WB; IHC; ICC.
PAM623Hu01 Polyclonal Antibody to HAUS Augmin Like Complex Subunit 7 (HAUS7) WB,IHC,ICC/IF
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM623Mu01 Recombinant HAUS Augmin Like Complex Subunit 7 (HAUS7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM623Mu01 Polyclonal Antibody to HAUS Augmin Like Complex Subunit 7 (HAUS7) WB; IHC
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM623Ra01 Recombinant HAUS Augmin Like Complex Subunit 7 (HAUS7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM623Ra01 Polyclonal Antibody to HAUS Augmin Like Complex Subunit 7 (HAUS7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 7 (HAUS7) ELISA Kit Customized Service Offer
  1. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of two proteins, S14 and UIP1, that interact with UCH37."FEBS Lett. 488:201-205(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Expressed STSs and transcription of human Xq28."Gene 187:185-191(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity."Curr. Biol. 19:816-826(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]