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Src Homology 2 Domain Containing Adapter Protein B (SHB)

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SH2 Domain Containing Adapter Protein B

Src Homology 2 Domain Containing Adapter Protein B (SHB)
CCC M223
HGNC 10838
MGI 98294
PubMed 19696098
UniProt Q15464
Wiki SHB
Many proteins involved in the regulation of cellular proliferation contain sequence motifs named SH2 and SH3 . These domains mediate interaction with other proteins; the SH2 domain interacts with tyrosine phosphorylation sites, while SH3 domains interact with proline-rich sequences. Many signal transduction pathways involve the induction of the formation of complexes of proteins such as growth factor receptors, adaptor proteins, and target enzymes through SH2 and SH3 interactions. Adaptor proteins are molecules with multiple protein interaction motifs that do not appear to have catalytic activity of their own but mediate the interaction of other proteins. The SHB gene encodes 2 such adaptor proteins (from 2 different start methionines) of 67 and 56 kD .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM223Hu01 Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM223Hu01 Polyclonal Antibody to Src Homology 2 Domain Containing Adapter Protein B (SHB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Src Homology 2 Domain Containing Adapter Protein B (SHB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Src Homology 2 Domain Containing Adapter Protein B (SHB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM223Mu01 Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM223Mu01 Polyclonal Antibody to Src Homology 2 Domain Containing Adapter Protein B (SHB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Src Homology 2 Domain Containing Adapter Protein B (SHB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Src Homology 2 Domain Containing Adapter Protein B (SHB) ELISA Kit Customized Service Offer
  1. "Shb is a ubiquitously expressed Src homology 2 protein."Oncogene 9:19-27(1994) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins."Oncogene 10:1475-1483(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb."Oncogene 13:955-961(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells."Cell Growth Differ. 9:757-766(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins."Oncogene 16:891-901(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells."J. Biol. Chem. 274:28050-28057(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis."Blood 95:3403-3411(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization."Exp. Cell Res. 257:245-254(2000) [PubMed] [Europe PMC] [Abstract]
  11. "NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway."Exp. Cell Res. 259:370-377(2000) [PubMed] [Europe PMC] [Abstract]
  12. "IL-2 receptor signaling through the Shb adapter protein in T and NK cells."Biochem. Biophys. Res. Commun. 296:929-936(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells."Eur. J. Biochem. 269:3279-3288(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells."Mol. Biol. Cell 13:2881-2893(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins."Mol. Med. 8:695-704(2002) [PubMed] [Europe PMC] [Abstract]
  16. "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells."Cell. Signal. 15:171-179(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration."J. Biol. Chem. 279:22267-22275(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling."Exp. Cell Res. 308:381-393(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]