NADH Dehydrogenase, Quinone 1 (NQO1)
[Edit]DHQU; DIA4; DTD; NMOR1; NMORI; QR1; Azoreductase; DT-diaphorase; Menadione reductase; Phylloquinone reductase; Quinone reductase 1; NAD(P)H:quinone oxidoreductase 1
![NADH Dehydrogenase, Quinone 1 (NQO1)](/upload/item/img/NADH-Dehydrogenase--Quinone-1-(NQO1)-80969.jpg)
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer.
Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL969Hu01 | Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APL969Hu01 | Active NADH Dehydrogenase, Quinone 1 (NQO1) | Cell culture; Activity Assays. | |
Antibodies | PAL969Hu01 | Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP; FCM |
MAL969Hu21 | Monoclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL969Hu | ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL969Mu01 | Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPL969Mu02 | Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAL969Mu01 | Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP. |
PAL969Mu02 | Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL969Mu | ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL969Ra01 | Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APL969Ra01 | Active NADH Dehydrogenase, Quinone 1 (NQO1) | Cell culture; Activity Assays. | |
Antibodies | PAL969Ra01 | Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP. |
MAL969Ra21 | Monoclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL969Ra | ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16."J. Biol. Chem. 263:13572-13578(1988) [PubMed] [Europe PMC] [Abstract]
- "Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin."Biochemistry 30:10647-10653(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)."J. Med. Chem. 42:4325-4330(1999) [PubMed] [Europe PMC] [Abstract]
- "Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release."Proc. Natl. Acad. Sci. U.S.A. 97:3177-3182(2000) [PubMed] [Europe PMC] [Abstract]
- "Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches."Biochemistry 40:15135-15142(2001) [PubMed] [Europe PMC] [Abstract]
- "Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones."Structure 9:659-667(2001) [PubMed] [Europe PMC] [Abstract]
- "The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol."Biochemistry 45:6372-6378(2006) [PubMed] [Europe PMC] [Abstract]
- "NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity."Cancer Res. 52:797-802(1992) [PubMed] [Europe PMC] [Abstract]
- "No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population."Hum. Mutat. 14:67-70(1999) [PubMed] [Europe PMC] [Abstract]