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NADH Dehydrogenase, Quinone 1 (NQO1)

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DHQU; DIA4; DTD; NMOR1; NMORI; QR1; Azoreductase; DT-diaphorase; Menadione reductase; Phylloquinone reductase; Quinone reductase 1; NAD(P)H:quinone oxidoreductase 1

NADH Dehydrogenase, Quinone 1 (NQO1)
CCC L969
HGNC 2874
MGI 103187
PubMed 22532167
RGD 2503
UniProt P15559
Wiki NQO1
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer.
Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL969Hu01 Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) Positive Control; Immunogen; SDS-PAGE; WB.
APL969Hu01 Active NADH Dehydrogenase, Quinone 1 (NQO1) Cell culture; Activity Assays.
Antibodies PAL969Hu01 Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP; FCM
MAL969Hu21 Monoclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP.
Assay Kits SEL969Hu ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL969Mu01 Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) Positive Control; Immunogen; SDS-PAGE; WB.
RPL969Mu02 Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL969Mu01 Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP.
PAL969Mu02 Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP.
Assay Kits SEL969Mu ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL969Ra01 Recombinant NADH Dehydrogenase, Quinone 1 (NQO1) Positive Control; Immunogen; SDS-PAGE; WB.
APL969Ra01 Active NADH Dehydrogenase, Quinone 1 (NQO1) Cell culture; Activity Assays.
Antibodies PAL969Ra01 Polyclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP.
MAL969Ra21 Monoclonal Antibody to NADH Dehydrogenase, Quinone 1 (NQO1) WB; IHC; ICC; IP.
Assay Kits SEL969Ra ELISA Kit for NADH Dehydrogenase, Quinone 1 (NQO1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16."J. Biol. Chem. 263:13572-13578(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin."Biochemistry 30:10647-10653(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)."J. Med. Chem. 42:4325-4330(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release."Proc. Natl. Acad. Sci. U.S.A. 97:3177-3182(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches."Biochemistry 40:15135-15142(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones."Structure 9:659-667(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol."Biochemistry 45:6372-6378(2006) [PubMed] [Europe PMC] [Abstract]
  12. "NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity."Cancer Res. 52:797-802(1992) [PubMed] [Europe PMC] [Abstract]
  13. "No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population."Hum. Mutat. 14:67-70(1999) [PubMed] [Europe PMC] [Abstract]