Delta Like 1 Homolog (dLK1)
[Edit]FA1; PREF1; Pref-1; ZOG; pG2; Protein delta homolog 1; Fetal antigen 1
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DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL437Hu01 | Recombinant Delta Like 1 Homolog (dLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPL437Hu02 | Recombinant Delta Like 1 Homolog (dLK1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAL437Hu01 | Polyclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. |
PAL437Hu02 | Polyclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL437Hu | ELISA Kit for Delta Like 1 Homolog (dLK1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL437Mu01 | Recombinant Delta Like 1 Homolog (dLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPL437Mu02 | Recombinant Delta Like 1 Homolog (dLK1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAL437Mu01 | Polyclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. |
PAL437Mu02 | Polyclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL437Mu | ELISA Kit for Delta Like 1 Homolog (dLK1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL437Ra01 | Recombinant Delta Like 1 Homolog (dLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAL437Ra21 | Monoclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. |
PAL437Ra01 | Polyclonal Antibody to Delta Like 1 Homolog (dLK1) | WB; IHC; ICC; IP. | |
Assay Kits | SEL437Ra | ELISA Kit for Delta Like 1 Homolog (dLK1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA."Biochim. Biophys. Acta 1261:223-232(1995) [PubMed] [Europe PMC] [Abstract]
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- "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2."Hum. Reprod. 8:635-641(1993) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]