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CASP8 And FADD Like Apoptosis Regulator (CFLAR)

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CASH; CASP8AP1; CLARP; Casper; FLAME1; FLIP; I-FLICE; MRIT; USURPIN; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; Caspase-eight-related protein; FADD-like antiapoptotic molecule 1

CASP8 And FADD Like Apoptosis Regulator (CFLAR)
CCC L332
HGNC 1876
MGI 1336166
PubMed 21368763
RGD 620847
UniProt O15519
Wiki CFLAR
Caspases are cysteine proteases that play a central role in apoptosis. Caspase-8 (FLICE) may be the first enzyme of the proteolytic cascade that is activated by the FAS ligand (FASL) and tumor necrosis factor (TNF). Caspase-8 is recruited to FAS and TNF receptor-1 (TNFR1) through interaction of its prodomain with the death effector domain (DED) of the receptor-associating protein FADD. The predicted 480-amino acid CASPER protein contains 2 DED-like modules at its N terminus and a C-terminal caspase-like protease domain. However, CASPER is not a caspase since it lacks several conserved amino acids found in all identified caspases. Northern blot analysis detected several CASPER transcripts, with highest expression in human skeletal muscle, pancreas, and heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL332Hu01 Recombinant CASP8 And FADD Like Apoptosis Regulator (CFLAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to CASP8 And FADD Like Apoptosis Regulator (CFLAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CASP8 And FADD Like Apoptosis Regulator (CFLAR) Polyclonal Antibody Customized Service Offer
Assay Kits SEL332Hu ELISA Kit for CASP8 And FADD Like Apoptosis Regulator (CFLAR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL332Mu01 Recombinant CASP8 And FADD Like Apoptosis Regulator (CFLAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL332Mu01 Polyclonal Antibody to CASP8 And FADD Like Apoptosis Regulator (CFLAR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for CASP8 And FADD Like Apoptosis Regulator (CFLAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for CASP8 And FADD Like Apoptosis Regulator (CFLAR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL332Ra01 Recombinant CASP8 And FADD Like Apoptosis Regulator (CFLAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL332Ra01 Polyclonal Antibody to CASP8 And FADD Like Apoptosis Regulator (CFLAR) WB; IHC
Assay Kits n/a CLIA Kit for CASP8 And FADD Like Apoptosis Regulator (CFLAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for CASP8 And FADD Like Apoptosis Regulator (CFLAR) ELISA Kit Customized Service Offer
  1. "Casper is a FADD- and caspase-related inducer of apoptosis."Immunity 6:751-763(1997) [PubMed] [Europe PMC] [Abstract]
  2. "MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death."Proc. Natl. Acad. Sci. U.S.A. 94:11333-11338(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Inhibition of death receptor signals by cellular FLIP."Nature 388:190-195(1997) [PubMed] [Europe PMC] [Abstract]
  4. "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis."J. Biol. Chem. 272:18542-18545(1997) [PubMed] [Europe PMC] [Abstract]
  5. "I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis."J. Biol. Chem. 272:17255-17257(1997) [PubMed] [Europe PMC] [Abstract]
  6. "CASH, a novel caspase homologue with death effector domains."J. Biol. Chem. 272:19641-19644(1997) [PubMed] [Europe PMC] [Abstract]
  7. "CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis."Proc. Natl. Acad. Sci. U.S.A. 94:10717-10722(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex." Cell Death Differ. 5:271-288(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The role of c-FLIP in modulation of CD95-induced apoptosis."J. Biol. Chem. 274:1541-1548(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis."J. Immunol. 162:5205-5211(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal."EMBO J. 22:2104-2116(2003) [PubMed] [Europe PMC] [Abstract]
  16. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]