Guanfacine (GFC)
Guanfacineis a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. Guanfacine has an oral bioavailability of 80%. There is no clear evidence of any first-pass metabolism. Elimination half-life is 17 hours with the major elimination route being renal. The principal metabolite is the 3-hydroxy-derivative, with evidence of moderate biotransformation, and the key intermediate being an epoxide. Guanfacine is a fairly selective agonist of the α2A adrenergic receptor.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Guanfacine (GFC) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanfacine (GFC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanfacine (GFC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanfacine (GFC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanfacine (GFC) ELISA Kit Customized Service Offer