Vinblastine (VBS)
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle and the kinetochore, each of which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers). Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules. Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin, and methotrexate in VBM chemotherapy for Stage IA or IIA Hodgkin lymphomas.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Vinblastine (VBS) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vinblastine (VBS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vinblastine (VBS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vinblastine (VBS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vinblastine (VBS) ELISA Kit Customized Service Offer