Topiramate (TPM)

Topiramate is an anticonvulsant (antiepilepsy) drug. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay.

Psychiatrists have used topiramate to treat bipolar disorder, and they sometimes use topiramate to augment psychotropics, or to counteract the weight gain associated with numerous antidepressants. In 2006, a Cochrane review concluded that there is insufficient evidence on which to base any recommendations regarding the use of topiramate in any phase of bipolar illness.[8] Another meta-analysis published in the Lancet demonstrated that topiramate was of no significant benefit in the treatment of bipolar mania.