Phenytoin (PY)
Phenytoin is an antiepileptic drug. It is useful to treat partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels. Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials. When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Phenytoin (PY) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phenytoin (PY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phenytoin (PY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phenytoin (PY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phenytoin (PY) ELISA Kit Customized Service Offer