Methyldopa (MDP)

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L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet; Aldoril; Dopamet; Dopegyt

Methyldopa (MDP)
Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)). Methyldopa has a dual mechanism of action: It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH). α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Methyldopa (MDP) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyldopa (MDP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyldopa (MDP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyldopa (MDP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyldopa (MDP) ELISA Kit Customized Service Offer