Lamivudine (LMV)

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Zeffix; Heptovir; Epivir; Epivir-HBV

Lamivudine (LMV)
Lamivudine (2′,3′-dideoxy-3′-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated. Lamivudine is an analogue of cytidine. It can inhibit both types of HIV reverse transcriptase and also the reverse transcriptase of hepatitis B. It is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Lamivudine (LMV) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lamivudine (LMV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lamivudine (LMV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lamivudine (LMV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lamivudine (LMV) ELISA Kit Customized Service Offer