Brefeldin A (BFA)
Brefeldin A is a lactone antibiotic produced by fungal organisms such as Eupenicillium brefeldianum. Brefeldin A inhibits protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus indirectly by preventing formation of COPII-mediated transport vesicles. Brefeldin A was initially isolated as an anti-viral antibiotic but is now primarily used in biological research to study protein transport. Brefeldin A forms a clear colorless solution at 10 mg/ml in both dichloromethane and methanol. In mammalian and yeast cells, the main target of brefeldin A appears to be a Guanine nucleotide exchange factor called Sar1. Sar1 mediates formation of transport vesicles by recruiting COPII coat proteins to cargo-bound receptor proteins found in the membrane of the rough ER. Inhibition of Sar1 activity prevents the anterograde movement of secretory proteins out of the ER.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Brefeldin A (BFA) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brefeldin A (BFA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brefeldin A (BFA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brefeldin A (BFA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brefeldin A (BFA) ELISA Kit Customized Service Offer