4-Hydroxycoumarin (4-HC)

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4-Coumarinol; Benzotetronic Acid; 4-Hydroxy Coumarin

4-Hydroxycoumarin (4-HC)
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one) by adding a hydroxy group at the 4 position to obtain "4-hydroxycoumarin" (or "4-hydroxychromen-2-one"; formally then renumbered as 2-hydroxychromen-4-one), then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). The large 3-position substituent is required for anticoagulant activity.
The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists (in the pharmaceutical sense) of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of 4-Hydroxycoumarin (4-HC) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to 4-Hydroxycoumarin (4-HC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 4-Hydroxycoumarin (4-HC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 4-Hydroxycoumarin (4-HC) CLIA Kit Customized Service Offer
n/a ELISA Kit for 4-Hydroxycoumarin (4-HC) ELISA Kit Customized Service Offer