Gemcitabine (GMT)
Gemcitabine is a nucleoside analog used as chemotherapy. Chemically gemcitabine is a nucleoside analog in which the hydrogen atoms on the 2' carbon of deoxycytidine are replaced by fluorine atoms. As with fluorouracil and other analogues of pyrimidines, the triphosphate analogue of gemcitabine replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as only one additional nucleoside can be attached to the "faulty" nucleoside, resulting in apoptosis. Another target of gemcitabine is the enzyme ribonucleotide reductase (RNR). The diphosphate analogue binds to RNR active site and inactivates the enzyme irreversibly. Once RNR is inhibited, the cell cannot produce the deoxyribonucleotides required for DNA replication and repair, and cell apoptosis is induced.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Gemcitabine (GMT) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gemcitabine (GMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gemcitabine (GMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gemcitabine (GMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gemcitabine (GMT) ELISA Kit Customized Service Offer